Brief Reports
11 March 2014
Vol. 58 No. 1 (2014)
https://doi.org/10.4081/ejh.2014.2358

Unexpected distribution of KRIT1 inside the nucleus: new insight in a complex molecular pathway

Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
cell nucleus, cerebral cavernous malformations, KRIT1, transcription, electron microscopy, immunocytochemistry.
3158
Views
795
Downloads
271
HTML

Authors

S. Marzo
University of Pavia, Italy.
V. Galimberti
University of Pavia, Italy.
M. Biggiogera
[email protected]
University of Pavia, Italy.
KRIT1 is an 84kDa protein that lacks any relevant catalytic domains, associated with the cerebral cavernous malformation disease. We have investigated by means of ultrastructural immunocytochemistry the nuclear distribution of KRIT1 in different cell lines, revealing its unexpected localization on actively transcribing nuclear domains such as the perichromatin fibrils and the nucleolar dense fibrillar component. These preliminary data indicate a still undescribed and unknown role for KRIT1 inside the nucleus.

Altmetrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
S. Marzo, University of Pavia
Dipartimento di Biologia e Biotecnologie "Lazzaro Spallanzani"
V. Galimberti, University of Pavia
Dipartimento di Biologia e Biotecnologie "Lazzaro Spallanzani"
M. Biggiogera, University of Pavia
Dipartimento di Biologia e Biotecnologie "Lazzaro Spallanzani"

How to Cite



Unexpected distribution of KRIT1 inside the nucleus: new insight in a complex molecular pathway. (2014). European Journal of Histochemistry, 58(1). https://doi.org/10.4081/ejh.2014.2358

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.